Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells.

ABSTRACT:

Background

We have previously reported that γ- and δ-tocotrienols (γ- and δ-T3) induce gene expression and apoptosis in human breast cancer cells (MDA-MB-231 and MCF-7). This effect is mediated, at least in part, by a specific binding and activation of the estrogen receptor-β (ERβ). Transcriptomic data obtained within our previous studies, interrogated by different bioinformatic tools, suggested the existence of an alternative pathway, activated by specific T3 forms and leading to apoptosis, also in tumor cells not expressing ER. In order to confirm this hypothesis, we conducted a study in HeLa cells, a line of human cervical cancer cells void of any canonical ER form.

Results

Cells were synchronized by starvation and treated either with a T3-rich fraction from palm oil (10-

SUBMITTER: Comitato R 

PROVIDER: S-EPMC5180413 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature