Accelerating the discovery of antibacterial compounds using pathway-directed whole cell screening.

ABSTRACT: Since the introduction of penicillin into the clinic in 1942, antibiotics have saved the lives of millions of people around the world. While penicillin and other traditional broad spectrum antibiotics were effective as monotherapies, the inexorable spread of antibiotic resistance has made alternative therapeutic approaches necessary. Compound combinations are increasingly seen as attractive options. Such combinations may include: lethal compounds; synthetically lethal compounds; or administering a lethal compound with a nonlethal compound that targets a virulence factor or a resistance factor. Regardless of the therapeutic strategy, high throughput screening is a key approach to discover potential leads. Unfortunately, the discovery of biologically active compounds that inhibit a desired p

SUBMITTER: Matano LM 

PROVIDER: S-EPMC5180449 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature