Vitamin D receptor is a novel transcriptional regulator for Axin1.

ABSTRACT:

Background

Axin1 is a scaffold protein in the β-catenin destruction complex, which, if disrupted, contributes to pathogenesis of various human diseases, including colorectal carcinogenesis and inflammatory bowel diseases (IBD). We have previously demonstrated that Salmonella infection promotes the degradation and plasma sequestration of Axin1, leading to bacterial invasiveness and inflammatory responses. Vitamin D and the vitamin D receptor (VDR) appear to be important regulators of IBD and colon cancer. Although VDR and Axin1 are all involved in intestinal inflammation, it remains unclear whether these processes are related or function independently. In the current study, we hypothesize that VDR is an important regulator for the maintenance of physiological level of Axin1.

Meth

SUBMITTER: Jin D 

PROVIDER: S-EPMC5180453 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature