Pharmacokinetics of First-Line Antituberculosis Drugs Using WHO Revised Dosage in Children With Tuberculosis With and Without HIV Coinfection.

ABSTRACT:

Background

Pharmacokinetic data on the first-line antituberculosis drugs using the World Health Organization (WHO) revised dosages for children are limited. We investigated the pharmacokinetics of these drugs in children who were mostly treated with revised dosages.

Methods

Children with tuberculosis on first-line therapy for at least 4 weeks had blood samples collected at predose, 1, 2, 4, and 8 hours postdose. Drug concentrations were determined by validated liquid chromatography mass spectrometry methods, and pharmacokinetic parameters were calculated using noncompartmental analysis. Factors associated with plasma peak concentration (C_max) and the area under the time-concentration curve 0-8 hours (AUC_0-8h) of each drug was examined using univariate a

SUBMITTER: Kwara A 

PROVIDER: S-EPMC5181357 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature