NCMine: Core-peripheral based functional module detection using near-clique mining.

ABSTRACT:

Motivation

The identification of functional modules from protein-protein interaction (PPI) networks is an important step toward understanding the biological features of PPI networks. The detection of functional modules in PPI networks is often performed by identifying internally densely connected subnetworks, and often produces modules with "core" and "peripheral" proteins. The core proteins are the ones having dense connections to each other in a module. The difference between core and peripheral proteins is important to understand the functional roles of proteins in modules, but there are few methods to explicitly elucidate the internal structure of functional modules at gene level.

Results

We propose NCMine, which is a novel network clustering method and visualization too

SUBMITTER: Tadaka S 

PROVIDER: S-EPMC5181566 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature