Predicting G protein-coupled receptor downstream signaling by tissue expression.

ABSTRACT:

Motivation

G protein-coupled receptors (GPCRs) are central to how cells respond to their environment and a major class of pharmacological targets. However, comprehensive knowledge of which pathways are activated and deactivated by these essential sensors is largely unknown. To better understand the mechanism of GPCR signaling system, we integrated five independent genome-wide expression datasets, representing 275 human tissues and cell lines, with protein-protein interactions and functional pathway data.

Results

We found that tissue-specificity plays a crucial part in the function of GPCR signaling system. Only a few GPCRs are expressed in each tissue, which are coupled by different combinations of G-proteins or β-arrestins to trigger specific downstream pathways. Based on t

SUBMITTER: Hao Y 

PROVIDER: S-EPMC5181570 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature