Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.

ABSTRACT:

Background

Great heterogeneity exists in survival and the interval between onset of motor symptoms and dementia symptoms across synucleinopathies. We aimed to identify genetic and pathological markers that have the strongest association with these features of clinical heterogeneity in synucleinopathies.

Methods

In this retrospective study, we examined symptom onset, and genetic and neuropathological data from a cohort of patients with Lewy body disorders with autopsy-confirmed α synucleinopathy (as of Oct 1, 2015) who were previously included in other studies from five academic institutions in five cities in the USA. We used histopathology techniques and markers to assess the burden of tau neurofibrillary tangles, neuritic plaques, α-synuclein inclusions, and other pathologi

SUBMITTER: Irwin DJ 

PROVIDER: S-EPMC5181646 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature