Anti-CD19 chimeric antigen receptor T-cell therapy for adult Philadelphia chromosome-positive acute lymphoblastic leukemia: Two case reports.

ABSTRACT:

Rationale

The presence of the Philadelphia chromosome (Ph) in acute lymphoblastic leukemia (ALL) has been associated with a high risk of disease relapse and a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT) is an established treatment for adults with Ph-positive ALL, but relapse remains the primary cause of treatment failure, and is associated with an extremely poor prognosis. The emergence of resistance to tyrosine kinase inhibitors (TKIs) poses a challenge for patients with disease relapses after initial treatment with TKI-containing regimens.

Patient concerns

Two patients with TKI-resistant recurrent Ph-positive ALL.

Diagnoses

Ph-positive ALL.

Interventions

Anti-CD19 CAR T-cell infusion.

Outcomes

One patient's bone marrow bla

SUBMITTER: Zhu YM 

PROVIDER: S-EPMC5181821 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature