A new 3-alkylpyridine alkaloid from the marine sponge Haliclona sp. and its cytotoxic activity.

ABSTRACT: A new alkaloid, 3-dodecyl pyridine containing a terminal cyano group (1), was isolated from the methanol extract of an Indonesia marine sponge Haliclona sp. Its chemical structure was determined by a combination of spectroscopic methods, including 1D and 2D NMR. Bioassay results indicated that compound 1 had moderate cytotoxity against tumour cell lines A549, MCF-7 and Hela with IC50 values of 41.8, 48.4 and 33.2 μM, respectively.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC5182040 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature