Low PLCE1 levels are correlated with poor prognosis in hepatocellular carcinoma.

ABSTRACT:

Background

Previous reports show that phospholipase C epsilon-1 (PLCE1) expression is positively correlated with esophageal squamous cell carcinoma and gastric cardia adenocarcinomas; however, the expression of PLCE1 in hepatocellular carcinoma (HCC) and its correlation with clinical outcome still remain unclear. The aim of this study was to explore the expression of PLCE1 in HCC tissue and to determine whether PLCE1 was a prognostic factor for HCC patients.

Materials and methods

PLCE1 levels in 20 paired HCC tissues and corresponding paracarcinomatous tissues was investigated by quantitative real-time polymerase chain reaction and Western blot assays. In addition, protein levels of PLCE1 in one normal liver epithelial cell and four

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC5182043 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature