Ontology highlight
ABSTRACT:
SUBMITTER: Sun W
PROVIDER: S-EPMC5182099 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Antiviral research 20161124
Although a group of FDA-approved drugs were previously identified with activity against Ebola virus (EBOV), most of them are not clinically useful because their human blood concentrations are not high enough to inhibit EBOV infection. We screened 795 unique three-drug combinations in an EBOV entry assay. Two sets of three-drug combinations, toremifene-mefloquine-posaconazole and toremifene-clarithromycin-posaconazole, were identified that effectively blocked EBOV entry and were further validated ...[more]