Use of antimullerian hormone to predict the menopausal transition in HIV-infected women.

ABSTRACT:

Background

HIV infection has been associated with early menopausal onset, which may have adverse long-term health consequences. Antimüllerian hormone, a biomarker of ovarian reserve and gonadal aging, is reduced in HIV-infected women.

Objective

We sought to assess the relationship of antimüllerian hormone to age of menopause onset in HIV-infected women.

Study design

We used antimüllerian hormone levels measured in plasma in 2461 HIV-infected participants from the Women's Interagency HIV Study to model the age at final menstrual period. Multivariable normal mixture models for censored data were used to identify factors associated with age at final menstrual period.

Results

Higher antimüllerian hormone at age 40 years was associated with later age at final menstr

SUBMITTER: Scherzer R 

PROVIDER: S-EPMC5182170 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature