Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma.

ABSTRACT:

Purpose

Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. To explore the genetic origins of MEC, we performed systematic genomic analyses of these tumors.

Experimental design

Whole-exome sequencing and gene copy-number analyses were performed for 18 primary cancers with matched normal tissue. FISH was used to determine the presence or absence of the MECT1-MAML2 translocation in 17 tumors.

Results

TP53 was the most commonly mutated gene in MEC (28%), and mutations were found only in intermediate- and high-grade tumors. Tumors with TP53 mutations had more mutations overall than tumors without TP53 mutations (P = 0.006). POU6F2 was the second most frequently mutated gene, found in three low-grade MECs with the same in-frame deletion. Somatic al

SUBMITTER: Kang H 

PROVIDER: S-EPMC5182193 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature