Association of SIRT6 Gene Polymorphisms with Human Longevity.

ABSTRACT:

Background

We aimed to identify the role of SIRT6 gene polymorphism rs350846 in human longevity.

Methods

SIRT6 C/G genotypes were determined using Taqman SNP Genotyping Assays in 169 long-lived inhabitants (LG group aged 90-110 yr), 158 healthy internal controls (internal control group; aged 26-82 yr) and 176 healthy external controls (external control group; aged 20-82 yr) without a family history of exceptional longevity. Statistical analysis was conducted using SPSS 16.0.

Results

BMI and TG level were lower in the longevity than in the two control groups, while serum LDL-c and HDL-c and SBP and DBP levels in long-lived individuals were higher than in the two control groups (P<0.01). The waist circumference was obviously different (P=0.00

SUBMITTER: Li Y 

PROVIDER: S-EPMC5182250 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature