Multi-template analysis of human perirhinal cortex in brain MRI: Explicitly accounting for anatomical variability.

ABSTRACT:

Rational

The human perirhinal cortex (PRC) plays critical roles in episodic and semantic memory and visual perception. The PRC consists of Brodmann areas 35 and 36 (BA35, BA36). In Alzheimer's disease (AD), BA35 is the first cortical site affected by neurofibrillary tangle pathology, which is closely linked to neural injury in AD. Large anatomical variability, manifested in the form of different cortical folding and branching patterns, makes it difficult to segment the PRC in MRI scans. Pathology studies have found that in ~97% of specimens, the PRC falls into one of three discrete anatomical variants. However, current methods for PRC segmentation and morphometry in MRI are based on single-template approaches, which may not be able to accurately model these discrete variants METHOD

SUBMITTER: Xie L 

PROVIDER: S-EPMC5183532 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature