Hypothermia in mouse is caused by adenosine A₁ and A₃ receptor agonists and AMP via three distinct mechanisms.

ABSTRACT: Small mammals have the ability to enter torpor, a hypothermic, hypometabolic state, allowing impressive energy conservation. Administration of adenosine or adenosine 5'-monophosphate (AMP) can trigger a hypothermic, torpor-like state. We investigated the mechanisms for hypothermia using telemetric monitoring of body temperature in wild type and receptor knock out (Adora1^-/-, Adora3^-/-) mice. Confirming prior data, stimulation of the A₃ adenosine receptor (AR) induced hypothermia via peripheral mast cell degranulation, histamine release, and activation of central histamine H₁ receptors. In contrast, A₁AR agonists and AMP both acted centrally to cause hypothermia. Commonly used, selective A₁AR agonists, including N⁶

SUBMITTER: Carlin JL 

PROVIDER: S-EPMC5183552 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature