BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis.

ABSTRACT: Neurotrophin receptors mediate a plethora of signals affecting neuronal survival. The p75 pan-neurotrophin receptor controls neuronal cell fate after its selective activation by immature and mature isoforms of all neurotrophins. It also exerts pleiotropic effects interacting with a variety of ligands in different neuronal or non-neuronal cells. In the present study, we explored the biophysical and functional interactions of a blood-brain-barrier (BBB) permeable, C17-spiroepoxy steroid derivative, BNN27, with p75^NTR receptor. BNN27 was recently shown to bind to NGF high-affinity receptor, TrkA. We now tested the p75^NTR-mediated effects of BNN27 in mouse Cerebellar Granule Neurons (CGNs), expressing p75^NTR, but not TrkA receptors. Our findings show that BNN27

SUBMITTER: Pediaditakis I 

PROVIDER: S-EPMC5183592 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature