Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-α G238A and G308A polymorphism?

ABSTRACT:

Introduction

Psoriasis is regarded as a complex autoimmune disease with strong genetic background. Psoriatic patients suffer from many comorbidities including hypertension, diabetes and cardiovascular diseases. Cytokines such as tumor necrosis factor α (TNF-α) may be a key player that triggers psoriasis and diabetes, hypertension and cardiac disease at the same time.

Aim

To evaluate genetic variations in the TNF-α region and its association with psoriasis and related comorbidities.

Material and methods

The study covered 129 psoriasis patients with three main subgroups with coronary artery disease (n = 41), hypertension (n = 35), and diabetes (n = 21). DNA samples were genotyped for TNF-α G308A and G238A polymorphisms by real-time polymerase chain

SUBMITTER: Isik S 

PROVIDER: S-EPMC5183775 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature