Influence of different second generation antipsychotics on the QTc interval: A pragmatic study.

ABSTRACT:

Aim

To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics (SGAs) in psychosis.

Methods

Data were drawn from a pragmatic, randomized head-to-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequence of the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s

SUBMITTER: Olsen RE 

PROVIDER: S-EPMC5183996 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature