HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C^∗12:02/C^∗14:03.

ABSTRACT: Natural killer (NK) cells control viral infection in part through the interaction between killer cell immunoglobulin-like receptors (KIRs) and their human leukocyte antigen (HLA) ligands. We investigated 504 anti-retroviral (ART)-free Japanese patients chronically infected with HIV-1 and identified two KIR/HLA combinations, KIR2DL2/HLA-C^∗12:02 and KIR2DL2/HLA-C^∗14:03, that impact suppression of HIV-1 replication. KIR2DL2⁺ NK cells suppressed viral replication in HLA-C^∗14:03⁺ or HLA-C^∗12:02⁺ cells to a significantly greater extent than did KIR2DL2^- NK cells in vitro. Functional analysis showed that the binding between HIV-1-derived peptide and HLA-C^∗14:03 or HLA-C^∗12:02 influenced K

SUBMITTER: Lin Z 

PROVIDER: S-EPMC5184766 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature