Type I IFN signaling facilitates the development of IL-10-producing effector CD8⁺ T cells during murine influenza virus infection.

ABSTRACT: Recent evidence has suggested that IL-10-producing effector CD8⁺ T cells play an important role in regulating excessive inflammation during acute viral infections. However, the cellular and molecular cues regulating the development of IL-10-producing effector CD8⁺ T cells are not completely defined. Here, we show that type I interferons (IFNs) are required for the development of IL-10-producing effector CD8⁺ T cells during influenza virus infection in mice. We find that type I IFNs can enhance IL-27 production by lung APCs, thereby facilitating IL-10-producing CD8⁺ T-cell development through a CD8⁺ T-cell-nonautonomous way. Surprisingly, we also demonstrate that direct type I IFN signaling in CD8⁺ T cells is required for the

SUBMITTER: Jiang L 

PROVIDER: S-EPMC5184847 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature