Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes.

ABSTRACT: Type 1 diabetes (T1D) is an auto-immune disease characterized by the selective destruction of the insulin secreting beta cells in the pancreas during an inflammatory phase known as insulitis. Patients with T1D are typically dependent on the administration of externally provided insulin in order to manage blood glucose levels. Whilst technological developments have significantly improved both the life expectancy and quality of life of these patients, an understanding of the mechanisms of the disease remains elusive. Animal models, such as the NOD mouse model, have been widely used to probe the process of insulitis, but there exist very few data from humans studied at disease onset. In this manuscript, we employ data from human pancreases collected close to the onset of T1D and propose a spa

SUBMITTER: Wedgwood KC 

PROVIDER: S-EPMC5186767 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature