Investigating Factors Associated with Thymic Regeneration after Chemotherapy in Patients with Lymphoma.

ABSTRACT: The factors involved in thymus regeneration after chemotherapy has not been sufficiently explored. This study was aimed to identify the clinical characteristics and single-nucleotide polymorphisms in the gene (IL7R) encoding IL-7Rα associated with thymus renewal after chemotherapy in Chinese Han individuals with lymphoma. The dynamics of thymic activity in 134 adults with Hodgkin lymphoma (HL) and B cell lymphoma from baseline to 12 months post-chemotherapy were analyzed by assessing thymic structural changes using serial computed tomography scans and correlating these with measurements of thymic output by concurrent analysis of single-joint T-cell receptor excision circles (sjTREC) and CD31⁺ recent thymic emigrants (RTE) in peripheral blood. The association of clinical v

SUBMITTER: Sun DP 

PROVIDER: S-EPMC5186774 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature