Neuroimmune Interface in the Comorbidity between Alcohol Use Disorder and Major Depression.

ABSTRACT: Bidirectional communication links operate between the brain and the body. Afferent immune-to-brain signals are capable of inducing changes in mood and behavior. Chronic heavy alcohol drinking, typical of alcohol use disorder (AUD), is one such factor that provokes an immune response in the periphery that, by means of circulatory cytokines and other neuroimmune mediators, ultimately causes alterations in the brain function. Alcohol can also directly impact the immune functions of microglia, the resident immune cells of the central nervous system (CNS). Several lines of research have established the contribution of specific inflammatory mediators in the development and progression of depressive illness. Much of the available evidence in this field stems from cross-sectional data on the immun

SUBMITTER: Neupane SP 

PROVIDER: S-EPMC5186784 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature