Tissue Specific Impacts of a Ketogenic Diet on Mitochondrial Dynamics in the BTBR^T+tf/j Mouse.

ABSTRACT: The ketogenic diet (KD) has been utilized as a dietary therapeutic for nearly a century. One experimental model particularly responsive to the KD is the BTBR^T+tf/j (BTBR) mouse, which displays phenotypic characteristics of autism spectrum disorder (ASD) and insulin resistance. Recently, the study of impaired mitochondrial function has become a focal point of research investigating the pathophysiology of ASD. As highly dynamic organelles, mitochondria undergo constant fluctuations in morphology, biogenesis, and quality control in order to maintain cellular homeostasis. An important modifier of mitochondrial dynamics is energy availability. Therefore, the aim of this study was to examine the impact of a KD on mitochondrial dynamics in the liver and brain (prefrontal cortex) of the

SUBMITTER: Newell C 

PROVIDER: S-EPMC5186794 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature