Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model.

ABSTRACT: Lactate has long been considered as a metabolic by-product of cells. Recently, this view has been changed by the observation that lactate can act as a signaling molecule and regulates critical functions of the immune system. We previously identified lactate as the component responsible for the modulation of innate immune epithelial response of fermented milk supernatants in vitro. We have also shown that lactate downregulates proinflammatory responses of macrophages and dendritic cells. So far, in vivo effects of lactate on intestinal inflammation have not been reported. We evaluated the effect of intrarectal administration of lactate in a murine model of colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). The increase in lactate concentration in colon promoted prot

SUBMITTER: Iraporda C 

PROVIDER: S-EPMC5187354 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature