Staphylococcus aureus Lpl Lipoproteins Delay G2/M Phase Transition in HeLa Cells.

ABSTRACT: The cell cycle is an ordered set of events, leading to cell growth and division into two daughter cells. The eukaryotic cell cycle consists of interphase (G₁, S, and G₂ phases), followed by the mitotic phase and G₀ phase. Many bacterial pathogens secrete cyclomodulins that interfere with the host cell cycle. In Staphylococcus aureus four cyclomodulins have been described so far that all represent toxins and are secreted into the culture supernatant. Here we show that the membrane-anchored lipoprotein-like proteins (Lpl), encoded on a genomic island called νSaα, interact with the cell cycle of HeLa cells. By comparing wild type and lpl deletion mutant it turned out that the lpl cluster is causative for the G2/M phase transition delay and

SUBMITTER: Nguyen MT 

PROVIDER: S-EPMC5187369 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature