The effect of pregabalin and s-ketamine in total knee arthroplasty patients: A randomized trial.

ABSTRACT:

Background and aims

Pain reduction is important for rehabilitation after total knee arthroplasty. Intra- and peri-articular infiltration with local anesthetics may be an alternative to commonly used locoregional techniques. Adding pregabalin orally and s-ketamine intravenously may further reduce postoperative pain.

Material and methods

This prospective, randomized, double-blind, placebo-controlled study compared two methods of perioperative analgesia. Control patients received a standardized multimodal postoperative analgesic regime of paracetamol, diclofenac, and piritramide-patient-controlled analgesia, including ropivacaine knee infiltration during surgery. The study group received pregabalin orally and s-ketamine intravenously as an additional medication to the standard

SUBMITTER: Kadic L 

PROVIDER: S-EPMC5187612 | biostudies-literature | 2016 Oct-Dec

REPOSITORIES: biostudies-literature