Epithelial self-healing is recapitulated by a 3D biomimetic E-cadherin junction.

ABSTRACT: Epithelial monolayers undergo self-healing when wounded. During healing, cells collectively migrate into the wound site, and the converging tissue fronts collide and form a stable interface. To heal, migrating tissues must form cell-cell adhesions and reorganize from the front-rear polarity characteristic of cell migration to the apical-basal polarity of an epithelium. However, identifying the "stop signal" that induces colliding tissues to cease migrating and heal remains an open question. Epithelial cells form integrin-based adhesions to the basal extracellular matrix (ECM) and E-cadherin-mediated cell-cell adhesions on the orthogonal, lateral surfaces between cells. Current biological tools have been unable to probe this multicellular 3D interface to determine the stop signal. We addres

SUBMITTER: Cohen DJ 

PROVIDER: S-EPMC5187740 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature