Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity.

ABSTRACT: Numerous therapeutically relevant small molecules have been identified from the screening of natural products (NPs) produced by environmental bacteria. These discovery efforts have principally focused on culturing bacteria from natural environments rich in biodiversity. We sought to assess the biosynthetic capacity of urban soil environments using a phylogenetic analysis of conserved NP biosynthetic genes amplified directly from DNA isolated from New York City park soils. By sequencing genes involved in the biosynthesis of nonribosomal peptides and polyketides, we found that urban park soil microbiomes are both rich in biosynthetic diversity and distinct from nonurban samples in their biosynthetic gene composition. A comparison of sequences derived from New York City parks to genes involve

SUBMITTER: Charlop-Powers Z 

PROVIDER: S-EPMC5187742 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature