Checkpoints to the Brain: Directing Myeloid Cell Migration to the Central Nervous System.

ABSTRACT: Myeloid cells are a unique subset of leukocytes with a diverse array of functions within the central nervous system during health and disease. Advances in understanding of the unique properties of these cells have inspired interest in their use as delivery vehicles for therapeutic genes, proteins, and drugs, or as "assistants" in the clean-up of aggregated proteins and other molecules when existing drainage systems are no longer adequate. The trafficking of myeloid cells from the periphery to the central nervous system is subject to complex cellular and molecular controls with several 'checkpoints' from the blood to their destination in the brain parenchyma. As important components of the neurovascular unit, the functional state changes associated with lineage heterogeneity of myeloid cell

SUBMITTER: Harrison-Brown M 

PROVIDER: S-EPMC5187830 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature