Peripheral Nerve Injury: Stem Cell Therapy and Peripheral Nerve Transfer.

ABSTRACT: Peripheral nerve injury can lead to great morbidity in those afflicted, ranging from sensory loss, motor loss, chronic pain, or a combination of deficits. Over time, research has investigated neuronal molecular mechanisms implicated in nerve damage, classified nerve injury, and developed surgical techniques for treatment. Despite these advancements, full functional recovery remains less than ideal. In this review, we discuss historical aspects of peripheral nerve injury and introduce nerve transfer as a therapeutic option, as well as an adjunct therapy to transplantation of Schwann cells and their stem cell derivatives for repair of the damaged nerve. This review furthermore, will provide an elaborated discussion on the sources of Schwann cells, including sites to harvest their progenitor

SUBMITTER: Sullivan R 

PROVIDER: S-EPMC5187901 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature