Neurotoxicity of a Biopesticide Analog on Zebrafish Larvae at Nanomolar Concentrations.

ABSTRACT: Despite the ever-increasing role of pesticides in modern agriculture, their deleterious effects are still underexplored. Here we examine the effect of A6, a pesticide derived from the naturally-occurring α-terthienyl, and structurally related to the endocrine disrupting pesticides anilinopyrimidines, on living zebrafish larvae. We show that both A6 and an anilinopyrimidine, cyprodinyl, decrease larval survival and affect central neurons at micromolar concentrations. Focusing on a superficial and easily observable sensory system, the lateral line system, we found that defects in axonal and sensory cell regeneration can be observed at much lower doses, in the nanomolar range. We also show that A6 accumulates preferentially in lateral line neurons and hair cells. We examined whether A6 affect

SUBMITTER: Nasri A 

PROVIDER: S-EPMC5187937 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature