Prognostic Value of the Cumulative Cisplatin Dose During Concurrent Chemoradiotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma: A Secondary Analysis of a Prospective Phase III Clinical Trial.

ABSTRACT:

Background

The objective of this study was to evaluate the prognostic value of the cumulative cisplatin dose (CCD) for long-term survival outcomes after concurrent chemoradiotherapy (CCRT) in locoregionally advanced nasopharyngeal carcinoma (NPC).

Methods

Patients were included in an open-label phase III multicenter randomized controlled trial performed at seven institutions in China, and the 298 patients receiving CCRT only were assessed. Patient survival between different CCD groups were compared.

Results

Median CCD for the 298 patients was 240 mg/m² (range, 40-320 mg/m²); 113 (37.9%) patients received a CCD of <240 (≤200) mg/m², and 185 (62.1%) received a CCD of ≥240 mg/m². For CCD of ≥240 mg/m² vs. <240 mg/m

SUBMITTER: Peng H 

PROVIDER: S-EPMC5189617 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature