Decline in Cognitive Function in Older Adults With Early-Stage Breast Cancer After Adjuvant Treatment.

ABSTRACT:

Background

The impact of chemotherapy on cognition among elderly patients has received little attention, although such patients are more prone to presenting with age-related cognitive deficits and/or cognitive decline during chemotherapy. The present study assessed the cognitive function in older adults treated for early-stage breast cancer (EBC).

Patients and methods

The participants were newly diagnosed EBC patients aged ≥65 years without previous systemic treatment or neurological or psychiatric disease and matched healthy controls. They underwent two assessments: before starting adjuvant therapy and after the end of chemotherapy (including doxorubicin ± docetaxel [CT+ group], n = 58) or radiotherapy for patients who did not receive chemotherapy (CT- group, n

SUBMITTER: Lange M 

PROVIDER: S-EPMC5189619 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature