Discordant Dry Eye Disease (An American Ophthalmological Society Thesis).

ABSTRACT:

Purpose

To improve understanding of dry eye disease and highlight a subgroup of patients who have a component of central sensitization and neuropathic pain contributing to their condition.

Methods

Prospective, cross-sectional, IRB-approved study comparing isolated dry eye disease (n=48) to fibromyalgia (positive control; n=23) and healthy (negative control; n=26) individuals with ocular surface examination, corneal confocal microscopy, quantitative sensory testing, and self-reported ocular symptoms and systemic associations. A subset of patients also underwent skin biopsy and/or brain neuroimaging. Dry eye patients were split into concordant (ie, those with dry eyes on examination) and discordant (ie, those with dry eye symptoms but normal examination) subgroups for further

SUBMITTER: Shtein RM 

PROVIDER: S-EPMC5189926 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature