Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis.

ABSTRACT:

Background

Major advances have been achieved in the characterization of early breast cancer (eBC) genomic profiles. Metastatic breast cancer (mBC) is associated with poor outcomes, yet limited information is available on the genomic profile of this disease. This study aims to decipher mutational profiles of mBC using next-generation sequencing.

Methods and findings

Whole-exome sequencing was performed on 216 tumor-blood pairs from mBC patients who underwent a biopsy in the context of the SAFIR01, SAFIR02, SHIVA, or Molecular Screening for Cancer Treatment Optimization (MOSCATO) prospective trials. Mutational profiles from 772 primary breast tumors from The Cancer Genome Atlas (TCGA) were used as a reference for comparing primary and mBC mutational profiles. Twelve genes (TP5

SUBMITTER: Lefebvre C 

PROVIDER: S-EPMC5189935 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature