Unknown

Dataset Information

0

Gene Expression Differences in Prostate Cancers between Young and Old Men.

ABSTRACT: Prostate cancer incidence is increasing in younger men. We investigated whether men diagnosed with Gleason 7 (3+4) T2 prostate cancer at younger ages (≤ 45 years, young cohort) had different mRNA and miRNA expression profiles than men diagnosed at older ages (71-74 years, older cohort). We identified differentially expressed genes (DEGs) related to tumor-normal differences between the cohorts. Subsequent pathway analysis of DEGs revealed that the young cohort had significantly more pronounced inflammatory and immune responses to tumor development compared to the older cohort. Further supporting a role of inflammation-induced immune-suppression in the development of early-onset prostate cancer, we observed significant up-regulation of CTLA4 and IDO1/TDO2 pathways in tumors of the young cohort. Moreover, over-expression of CTLA4 and IDO1 was significantly associated with biochemical recurrence. Our results provide clues on the mechanisms of tumor development and point to potential biomarkers for early detection and treatment for prostate cancer in young men.

SUBMITTER: Ding Y 

PROVIDER: S-EPMC5189936 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Gene Expression Differences in Prostate Cancers between Young and Old Men.

Ding Yuanchun Y   Wu Huiqing H   Warden Charles C   Steele Linda L   Liu Xueli X   Iterson M van MV   Wu Xiwei X   Nelson Rebecca R   Liu Zheng Z   Yuan Yate-Ching YC   Neuhausen Susan L SL  

PLoS genetics 20161227 12

Prostate cancer incidence is increasing in younger men. We investigated whether men diagnosed with Gleason 7 (3+4) T2 prostate cancer at younger ages (≤ 45 years, young cohort) had different mRNA and miRNA expression profiles than men diagnosed at older ages (71-74 years, older cohort). We identified differentially expressed genes (DEGs) related to tumor-normal differences between the cohorts. Subsequent pathway analysis of DEGs revealed that the young cohort had significantly more pronounced in  ...[more]

Similar Datasets

Unknown Differences in genome-wide gene expression response in peripheral blood mononuclear cells between young and old men upon caloric restriction.
| S-EPMC4968441 | biostudies-literature
Transcriptomics Differences in genome-wide gene expression response in PBMCs between young and old men upon caloric restriction
2016-10-24 | GSE63117 | GEO
Transcriptomics Differences in genome-wide gene expression response in PBMCs between young and old men upon caloric restriction
2016-10-24 | E-GEOD-63117 | biostudies-arrayexpress
Transcriptomics RNA-seq reveals differences in liver gene expression rhythms between young and old mice
2019-12-31 | GSE113745 | GEO
Unknown Gene Expression Analysis Reveals Novel Gene Signatures Between Young and Old Adults in Human Prefrontal Cortex.
| S-EPMC6119720 | biostudies-literature
Unknown Differential Gene Expression Analysis of Whole Blood Transcriptome Between Young and Old Border Collie Dogs.
| S-EPMC11860333 | biostudies-literature
Unknown Prostate cancer in young men represents a distinct clinical phenotype: gene expression signature to predict early metastases.
| S-EPMC8081383 | biostudies-literature
Unknown DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers.
| S-EPMC2605660 | biostudies-literature
Proteomics Myelin proteome differences in old and young mice
2023-10-19 | PXD040719 | Pride
Genomics RNA-seq reveals differences in liver gene expression rhythms between young and old mice
| PRJNA453909 | ENA