Cell Fate Decision as High-Dimensional Critical State Transition.

ABSTRACT: Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage requires broad changes of their gene expression profile. But how progenitor cells overcome the stability of their gene expression configuration (attractor) to exit the attractor in one direction remains elusive. Here we show that commitment of blood progenitor cells to the erythroid or myeloid lineage is preceded by the destabilization of their high-dimensional attractor state, such that differentiating cells undergo a critical state transition. Single-cell resolution analysis of gene expression in populations of differentiating cells affords a new quantitative index for predicting critical transitions in a high-dimensional state space based on decrease of correlation between cells and concomitant i

SUBMITTER: Mojtahedi M 

PROVIDER: S-EPMC5189937 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature