The inhibitor of kappa B kinase-epsilon regulates MMP-3 expression levels and can promote lung metastasis.

ABSTRACT: The factors that determine the ability of metastatic tumor cells to expand and grow in specific secondary site(s) are not yet fully understood. Matrix metalloproteinases (MMP) were identified as potential regulators of the site-specificity of metastasis. We found that lung carcinoma cells ectopically expressing high levels of the receptor for the type I insulin like growth factor receptor (M27(R) cells) had a significant reduction in MMP-3 expression levels and this coincided with reduced metastasis to the lung. We used these cells to further investigate signaling pathways regulating MMP-3 expression and the role that MMP-3 plays in lung metastasis. We show that ectopic IκB kinase ɛ (IKKɛ) expression in these cells partly restored MMP-3 expression levels and also sensitized MMP-3 transcrip

SUBMITTER: Seccareccia E 

PROVIDER: S-EPMC5189963 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature