Reduction of AZGP1 predicts poor prognosis in esophageal squamous cell carcinoma patients in Northern China.

ABSTRACT:

Background

As a key regulator in lipid mobilization, AZGP1 has been reported to play a significant role in various cancers. This study was carried out to investigate the role of AZGP1 in the development of esophageal squamous cell carcinoma (ESCC) patients in Northern China.

Materials and methods

Through the application of quantitative real-time polymerase chain reaction and immunohistochemical staining, AZGP1 expression in ESCC tissues from Northern China was examined.

Results

Decreased expression of AZGP1 was observed in ~60% ESCC patients. AZGP1 downregulation was significantly associated with lymph node metastasis (P=0.035), advanced clinical stage (P=0.018), poor prognosis for 5-year disease-specific survival (DSS; P<0.001), local recurrence-

SUBMITTER: Tang H 

PROVIDER: S-EPMC5189973 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature