High-density lipoprotein cholesterol as a predictor of poor survival in patients with nasopharyngeal carcinoma.

ABSTRACT:

Purpose

We aimed to assess the prognostic value of pretreatment high density lipoprotein cholesterol (HDL-C) levels in patients with nasopharyngeal carcinoma (NPC) and investigate the possible biological effects of these lipoproteins on NPC cells in vitro.

Experimental design

We examined the prognostic value of pretreatment HDL-C levels in 2443 patients with non-metastatic NPC from three independent institutions. The Cox proportional hazard model and log-rank test were used to analyze the correlation between HDL-C levels and overall survival (OS). Cell growth, colony formation, and apoptotic assays were used to determine the biological functions of HDL on NPC cells in vitro. All of the statistical tests were two-sided.

Results

OS was decreased in patients with high pr

SUBMITTER: Liu YY 

PROVIDER: S-EPMC5190001 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature