Novel histopathologic feature identified through image analysis augments stage II colorectal cancer clinical reporting.

ABSTRACT: A number of candidate histopathologic factors show promise in identifying stage II colorectal cancer (CRC) patients at a high risk of disease-specific death, however they can suffer from low reproducibility and none have replaced classical pathologic staging. We developed an image analysis algorithm which standardized the quantification of specific histopathologic features and exported a multi-parametric feature-set captured without bias. The image analysis algorithm was executed across a training set (n = 50) and the resultant big data was distilled through decision tree modelling to identify the most informative parameters to sub-categorize stage II CRC patients. The most significant, and novel, parameter identified was the 'sum area of poorly differentiated clusters' (AreaPDC). This fea

SUBMITTER: Caie PD 

PROVIDER: S-EPMC5190104 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature