The interactome as a tree--an attempt to visualize the protein-protein interaction network in yeast.

ABSTRACT: The refinement and high-throughput of protein interaction detection methods offer us a protein-protein interaction network in yeast. The challenge coming along with the network is to find better ways to make it accessible for biological investigation. Visualization would be helpful for extraction of meaningful biological information from the network. However, traditional ways of visualizing the network are unsuitable because of the large number of proteins. Here, we provide a simple but information-rich approach for visualization which integrates topological and biological information. In our method, the topological information such as quasi-cliques or spoke-like modules of the network is extracted into a clustering tree, where biological information spanning from protein functional annota

SUBMITTER: Lu H 

PROVIDER: S-EPMC519110 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature