Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila.

ABSTRACT: Transgenerational effects on health and development of early-life nutrition have gained increased attention recently. However, the underlying mechanisms of transgenerational transmission are only starting to emerge, with epigenetics as perhaps the most important mechanism. We recently reported the first animal model to study transgenerational programming of longevity after early-life dietary manipulations, enabling investigations to identify underlying epigenetic mechanisms. We report here that post-eclosion dietary manipulation (PDM) with a low-protein (LP) diet upregulates the protein level of E(z), an H3K27 specific methyltransferase, leading to higher levels of H3K27 trimethylation (H3K27me3). This PDM-mediated change in H3K27me3 corresponded with a shortened longevity of F0 flies as w

SUBMITTER: Xia B 

PROVIDER: S-EPMC5191882 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature