Quantitative measurement of cerebral blood volume using velocity-selective pulse trains.

ABSTRACT:

Purpose

To develop a non-contrast-enhanced MRI method for cerebral blood volume (CBV) mapping using velocity-selective (VS) pulse trains.

Methods

The new pulse sequence applied velocity-sensitive gradient waveforms in the VS label modules and velocity-compensated ones in the control scans. Sensitivities to the gradient imperfections (e.g., eddy currents) were evaluated through phantom studies. CBV quantification procedures based on simulated labeling efficiencies for arteriolar, capillary, and venular blood as a function of cutoff velocity (Vc) are presented. Experiments were conducted on healthy volunteers at 3T to examine the effects of unbalanced diffusion weighting, cerebrospinal (CSF) contamination and variation of Vc.

Results

Phantom results of the used VS pulse

SUBMITTER: Liu D 

PROVIDER: S-EPMC5191941 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature