Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy.

ABSTRACT: The development of a tuberculosis (TB) vaccine that induces sterilizing immunity to Mycobacterium tuberculosis infection has been elusive. Absence of sterilizing immunity induced by TB vaccines may be due to delayed activation of mucosal dendritic cells (DCs), and subsequent delay in antigen presentation and activation of vaccine-induced CD4⁺ T-cell responses. Here we show that pulmonary delivery of activated M. tuberculosis antigen-primed DCs into vaccinated mice, at the time of M. tuberculosis exposure, can overcome the delay in accumulation of vaccine-induced CD4⁺ T-cell responses. In addition, activating endogenous host CD103⁺ DCs and the CD40-CD40L pathway can similarly induce rapid accumulation of vaccine-induced lung CD4⁺ T-cell responses

SUBMITTER: Griffiths KL 

PROVIDER: S-EPMC5192216 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature