Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory.

ABSTRACT: Neural plasticity is associated with memory formation. The coordinated refinement and interaction between cortical glutamatergic and GABAergic neurons remain elusive in associative memory, which we examine in a mouse model of associative learning. In the mice that show odorant-induced whisker motion after pairing whisker and odor stimulations, the barrel cortical glutamatergic and GABAergic neurons are recruited to encode the newly learnt odor signal alongside the innate whisker signal. These glutamatergic neurons are functionally upregulated, and GABAergic neurons are refined in a homeostatic manner. The mutual innervations between these glutamatergic and GABAergic neurons are upregulated. The analyses by high throughput sequencing show that certain microRNAs related to regulating synapse

SUBMITTER: Yan F 

PROVIDER: S-EPMC5192352 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature