Different Phases of Breast Cancer Cells: Raman Study of Immortalized, Transformed, and Invasive Cells.

ABSTRACT: Breast cancer is the most prevalent cause of cancer-associated death in women the world over, but if detected early it can be treated successfully. Therefore, it is important to diagnose this disease at an early stage and to understand the biochemical changes associated with cellular transformation and cancer progression. Deregulated lipid metabolism has been shown to contribute to cell transformation as well as cancer progression. In this study, we monitored the biomolecular changes associated with the transformation of a normal cell into an invasive cell associated with breast cancer using Raman microspectroscopy. We have utilized primary normal breast cells, and immortalized, transformed, non-invasive, and invasive breast cancer cells. The Raman spectra were acquired from all these cell

SUBMITTER: Chaturvedi D 

PROVIDER: S-EPMC5192377 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature