Subjective Mood in Young Unmedicated Depressed Women under High and Low Sleep Pressure Conditions.

ABSTRACT: Diurnal mood variations are one of the core symptoms in depression, and total sleep deprivation (SD) can induce rapid, short-lasting clinical improvement in depressed patients. Here, we investigated if differential sleep pressure conditions impact on subjective mood levels in young women with major depressive disorder (MDD) without sleep disturbances, and in healthy controls. Eight healthy and eight MDD women underwent 40-h SD (high sleep pressure) and 40-h multiple NAP (low sleep pressure) protocols under constant routine conditions during which subjective mood was assessed every 30-min. MDD women rated overall significantly worse mood than controls, with minimal values for both groups during the biological night (ca. 4 a.m.), under high and low sleep pressure conditions. During SD, night

SUBMITTER: Birchler-Pedross A 

PROVIDER: S-EPMC5192432 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature